pan-PIM inhibitor 17
Modify Date: 2024-02-04 17:01:51
pan-PIM inhibitor 17 structure
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Common Name | pan-PIM inhibitor 17 | ||
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| CAS Number | 1681021-52-2 | Molecular Weight | 374.869 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of pan-PIM inhibitor 17pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively; disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM; demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model. |
| Name | pan-PIM inhibitor 17 |
|---|
| Description | pan-PIM inhibitor 17 is a potent, selective, orally available inhibitor of Pim kinase with IC50 of 0.8, 5.1 and 1.8 nM for Pim1, 2 and 3, respectively; disaplays broad selectivity in an internal panel of 192 kinases, only eight kinases were inhibited above 50% at 1 uM; demonstrates cellular biomarker pS6 inhibition with EC50 of 27 nM, shows tumor growth inhibition in a KG1 tumor-bearing mouse model. |
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| References | References 1. Barberis C, et al. Bioorg Med Chem Lett. 2018 Dec 10. pii: S0960-894X(18)30949-1. 2. Barberis C, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4735-4740. 3. Guo Z, et al. Blood. 2014 Sep 11;124(11):1777-89. View Related Products by Target Pim |
| Molecular Formula | C19H23ClN4O2 |
|---|---|
| Molecular Weight | 374.869 |