1848233-57-7
1848233-57-7 structure
- Name: DH-376
- Chemical Name: DH-376
- CAS Number: 1848233-57-7
- Molecular Formula: C31H28F2N4O3
- Molecular Weight: 542.587
- Create Date: 2020-01-12 09:58:49
- Modify Date: 2024-04-11 10:00:02
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DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively; shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 (pIC50=7.0) and PLA2G7; significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model.
| Name | DH-376 |
|---|
| Description | DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively; shows excellent selectivity for DAGLs with the only detectable serine hydrolase off-targets being ABHD6 (pIC50=7.0) and PLA2G7; significantly decreases whole brain levels of 2-AG, anandamide, and arachidonic acid in the mouse LPS inflammatory pain model. |
|---|---|
| References | References 1. Ogasawara D, et al. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33. View Related Products by Target Diacylglycerol Lipase (DAGL) |
| Molecular Formula | C31H28F2N4O3 |
|---|---|
| Molecular Weight | 542.587 |