1951448-73-9
1951448-73-9 structure
- Name: MK-8353 hydrochloride
- Chemical Name: MK-8353 hydrochloride
- CAS Number: 1951448-73-9
- Molecular Formula: C37H42ClN9O3S
- Molecular Weight: 728.313
- Create Date: 2020-01-19 21:46:56
- Modify Date: 2023-01-14 22:51:22
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MK-8353 hydrochloride (SCH-900353) is a highly potent, orally bioavailable, dual-specificity ERK1/2 inhibitor with IC50 of 23.0/8.8 nM, respectively; inhibits nonactivated ERK2 with IC50 of 0.5 nM, demonstrates excellent kinase selectivity over a 227-human kinase panel; decreases pERK1, pERK2, and ribosomal S6 kinase (pRSK) proteins, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells, inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; exhibits in vivo antitumor activity against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model. Colon Cancer Phase 1 Clinical
| Name | MK-8353 hydrochloride |
|---|
| Description | MK-8353 hydrochloride (SCH-900353) is a highly potent, orally bioavailable, dual-specificity ERK1/2 inhibitor with IC50 of 23.0/8.8 nM, respectively; inhibits nonactivated ERK2 with IC50 of 0.5 nM, demonstrates excellent kinase selectivity over a 227-human kinase panel; decreases pERK1, pERK2, and ribosomal S6 kinase (pRSK) proteins, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells, inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; exhibits in vivo antitumor activity against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model. Colon Cancer Phase 1 Clinical |
|---|---|
| References | References 1. Moschos SJ, et al. JCI Insight. 2018 Feb 22;3(4). pii: 92352. View Related Products by Target ERK Colon Cancer |
| Molecular Formula | C37H42ClN9O3S |
|---|---|
| Molecular Weight | 728.313 |