1982347-43-2
1982347-43-2 structure
- Name: VK4-116
- Chemical Name: VK4-116
- CAS Number: 1982347-43-2
- Molecular Formula: C26H33ClN4O3
- Molecular Weight: 485.025
- Create Date: 2020-01-20 19:18:55
- Modify Date: 2023-01-11 13:41:56
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VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R; inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization, also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats.
| Name | VK4-116 |
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| Description | VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R; inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization, also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats. |
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| References | References 1. You ZB, et al. Neuropsychopharmacology. 2018 Nov 27. doi: 10.1038/s41386-018-0284-5. 2. Kumar V, et al. J Med Chem. 2016 Aug 25;59(16):7634-50. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C26H33ClN4O3 |
|---|---|
| Molecular Weight | 485.025 |