2094547-67-6
2094547-67-6 structure
- Name: EN40
- Chemical Name: ALDH3A1 inhibitor EN40
- CAS Number: 2094547-67-6
- Molecular Formula: C13H15NO2
- Molecular Weight: 217.268
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
- Create Date: 2020-01-12 13:58:50
- Modify Date: 2024-01-19 20:03:37
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ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM; also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes; specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1, inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo.
| Name | ALDH3A1 inhibitor EN40 |
|---|
| Description | ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM; also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes; specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1, inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo. |
|---|---|
| References | References 1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. View Related Products by Target Aldehyde Dehydrogenase (ALDH) |
| Molecular Formula | C13H15NO2 |
|---|---|
| Molecular Weight | 217.268 |