2101739-18-6

2101739-18-6 structure

Name: RAD51-IN-17
Chemical Name: RAD51-IN-17
CAS Number: 2101739-18-6
Molecular Formula: C₂₂H₁₆ClN₃O
Molecular Weight: 373.84
Catalog: Signaling Pathways Cell Cycle/DNA Damage RAD51
Create Date: 2020-01-12 10:11:49
Modify Date: 2024-09-19 19:21:18
RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines; also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation; a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.

Name	RAD51-IN-17

Description	RAD51-IN-17 is a quinazolinone derivative that inhibts homologous recombinase RAD51, effectively inhibits both RAD51 foci formation in response to DNA damage, and proliferation of TNBC cell lines; also sensitizes aggressive metastatic TNBC to DNA damage induced by irradiation; a valuable research tool for developing combination therapies to overcome RAD51 driven resistance and relapse in a variety of cancers.
References	References 1. Ward A, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3096-3100. View Related Products by Target DNA Repair Protein