2126134-01-6
2126134-01-6 structure
- Name: CCT 365623
- Chemical Name: CCT 365623
- CAS Number: 2126134-01-6
- Molecular Formula: C18H17NO4S3
- Molecular Weight: 407.517
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
- Create Date: 2020-01-11 18:38:51
- Modify Date: 2023-01-16 17:05:15
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CCT 365623(CCT365623, CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM; inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF, also activates SMAD2 and downregulates MATN2; delays the growth of primary and metastatic tumour cells in vivo.
| Name | CCT 365623 |
|---|
| Description | CCT 365623(CCT365623, CCT-365623) is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM; inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF, also activates SMAD2 and downregulates MATN2; delays the growth of primary and metastatic tumour cells in vivo. |
|---|---|
| References | References 1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909. View Related Products by Target Other Targets |
| Molecular Formula | C18H17NO4S3 |
|---|---|
| Molecular Weight | 407.517 |