2126749-48-0
2126749-48-0 structure
- Name: SU-909
- Chemical Name: SU-909
- CAS Number: 2126749-48-0
- Molecular Formula: C13H10N6O2S
- Molecular Weight: 314.323
- Create Date: 2020-01-20 14:01:56
- Modify Date: 2024-04-08 15:49:03
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SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.
| Name | SU-909 |
|---|
| Description | SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM); inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway. |
|---|---|
| References | References 1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066. View Related Products by Target IκB kinase (IKK) |
| Molecular Formula | C13H10N6O2S |
|---|---|
| Molecular Weight | 314.323 |