2126784-39-0
2126784-39-0 structure
- Name: VU 6010572
- Chemical Name: VU 6010572
- CAS Number: 2126784-39-0
- Molecular Formula: C20H18FNO3
- Molecular Weight: 339.366
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2020-01-20 12:22:56
- Modify Date: 2024-02-17 17:25:18
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A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM; show no inhibition for mGlu2 (IC50>30 uM); displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).
| Name | VU 6010572 |
|---|
| Description | A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM; show no inhibition for mGlu2 (IC50>30 uM); displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.). |
|---|---|
| References | References 1. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930. View Related Products by Target mGluR |
| Molecular Formula | C20H18FNO3 |
|---|---|
| Molecular Weight | 339.366 |