VU 6010572

Modify Date: 2024-02-17 17:25:18

VU 6010572 Structure
VU 6010572 structure
Common Name VU 6010572
CAS Number 2126784-39-0 Molecular Weight 339.366
Density N/A Boiling Point N/A
Molecular Formula C20H18FNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU 6010572


A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM; show no inhibition for mGlu2 (IC50>30 uM); displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).

 Names

Name VU 6010572

 VU 6010572 Biological Activity

Description A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM; show no inhibition for mGlu2 (IC50>30 uM); displays improved physiochemical properties and in vivo efficacy in a mouse tail suspension test (MED = 3 mg/kg i.p.).
References References 1. Engers JL, et al. ACS Med Chem Lett. 2017 Aug 15;8(9):925-930. View Related Products by Target mGluR

 Chemical & Physical Properties

Molecular Formula C20H18FNO3
Molecular Weight 339.366
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