2135880-19-0
2135880-19-0 structure
- Name: Syn-TEF1
- Chemical Name: Syn-TEF1
- CAS Number: 2135880-19-0
- Molecular Formula: C77H104ClN23O16S
- Molecular Weight: 1675.334
- Create Date: 2020-01-12 12:45:49
- Modify Date: 2025-08-25 19:07:10
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Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci; targets the DNA sequence 5'-AAGAAGAAG-3', activate FXN expression in primary patient cells and patient-derived fibroblasts, iPSCs, cardiomyocytes, sensory neurons, and mouse xenografts.
| Name | Syn-TEF1 |
|---|
| Description | Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci; targets the DNA sequence 5'-AAGAAGAAG-3', activate FXN expression in primary patient cells and patient-derived fibroblasts, iPSCs, cardiomyocytes, sensory neurons, and mouse xenografts. |
|---|---|
| References | References 1. Erwin GS, et al. Science. 2017 Dec 22;358(6370):1617-1622. View Related Products by Target Other Targets |
| Molecular Formula | C77H104ClN23O16S |
|---|---|
| Molecular Weight | 1675.334 |