2170867-89-5
2170867-89-5 structure
- Name: Diprovocim
- Chemical Name: Diprovocim
- CAS Number: 2170867-89-5
- Molecular Formula: C56H56N6O6
- Molecular Weight: 909.1
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2020-01-12 08:12:51
- Modify Date: 2025-08-25 14:33:09
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Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages; induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC; induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice.
| Name | Diprovocim |
|---|
| Description | Diprovocim is a potent Toll-like receptor TLR1/TLR2 agonist that induces dose-dependent TNF production with EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages; induces TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also induces IL-6 production by mouse BMDC; induces phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activates conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice. |
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| References | References 1. Wang Y, et al. Proc Natl Acad Sci U S A. 2018 Aug 27. pii: 201809232. View Related Products by Target Toll-like Receptor (TLR) |
| Molecular Formula | C56H56N6O6 |
|---|---|
| Molecular Weight | 909.1 |