2209057-94-1
2209057-94-1 structure
- Name: T-3861174
- Chemical Name: T-3861174
- CAS Number: 2209057-94-1
- Molecular Formula: C26H25FN6O2
- Molecular Weight: 472.524
- Create Date: 2020-01-12 14:24:51
- Modify Date: 2025-07-26 11:40:22
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T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM; induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway; exhibits significant tumor growth inhibition inSK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses.
| Name | T-3861174 |
|---|
| Description | T-3861174 is a novel small molecule prolyl tRNA synthetase (PRS) with binding IC50 of 2.3 nM; induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway; exhibits significant tumor growth inhibition inSK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses. |
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| References | References 1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654. View Related Products by Target Other Targets |
| Molecular Formula | C26H25FN6O2 |
|---|---|
| Molecular Weight | 472.524 |