2230731-99-2

2230731-99-2 structure

Name: KDOAM-25
Chemical Name: KDOAM-25
CAS Number: 2230731-99-2
Molecular Formula: C₁₅H₂₅N₅O₂
Molecular Weight: 307.398
Create Date: 2020-01-11 20:05:50
Modify Date: 2024-01-08 13:41:56
KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.

Name	KDOAM-25

Description	KDOAM-25 (KDM5 inhibitor KDOAM 25) is a potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively; weakly inhibits KDM4C/KDM2B (IC50=4.8/4.4 uM) and good selectivity over other demethylases; most potently inhibits KDM5B (IC50=50 uM) and increases H3K4me3 levels in Hela cells; increases global H3K4 methylation, causes G1 cell-cycle arrest and impairs cell proliferation in multiple myeloma MM1S cells.
References	References 1. Tumber A, et al. Cell Chem Biol. 2017 Mar 16;24(3):371-380. View Related Products by Target Histone Demethylase