311814-78-5
311814-78-5 structure
- Name: SR31527
- Chemical Name: SR31527
- CAS Number: 311814-78-5
- Molecular Formula: C15H14ClN3OS
- Molecular Weight: 319.807
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Kinesin
- Create Date: 2020-01-11 18:46:49
- Modify Date: 2024-01-13 23:08:49
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SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.
| Name | SR31527 |
|---|
| Description | SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts. |
|---|---|
| References | References 1. Zhang W, et al. Biochem J. 2016 Apr 15;473(8):1027-35. 2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41. View Related Products by Target Kinesin |
| Molecular Formula | C15H14ClN3OS |
|---|---|
| Molecular Weight | 319.807 |