SR31527
Modify Date: 2024-01-13 23:08:49
SR31527 structure
|
Common Name | SR31527 | ||
|---|---|---|---|---|
| CAS Number | 311814-78-5 | Molecular Weight | 319.807 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H14ClN3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SR31527SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts. |
| Name | SR31527 |
|---|
| Description | SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts. |
|---|---|
| References | References 1. Zhang W, et al. Biochem J. 2016 Apr 15;473(8):1027-35. 2. Yukawa M, et al. Fungal Genet Biol. 2018 Apr 21;116:33-41. View Related Products by Target Kinesin |
| Molecular Formula | C15H14ClN3OS |
|---|---|
| Molecular Weight | 319.807 |