425373-68-8
425373-68-8 structure
- Name: C188-9
- Chemical Name: C188-9
- CAS Number: 425373-68-8
- Molecular Formula: C28H23NO4S
- Molecular Weight: 469.555
- Create Date: 2020-01-12 12:06:50
- Modify Date: 2024-02-27 11:02:16
-
A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines; prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo. Solid Tumors Phase 1 Clinical
| Name | C188-9 |
|---|
| Description | A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines; prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo. Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Redell MS, et al. Blood. 2011 May 26;117(21):5701-9. 2. Bharadwaj U, et al. Oncotarget. 2016 May 3;7(18):26307-30. 3. Jung KH, et al. Clin Cancer Res. 2017 Sep 15;23(18):5537-5546. 4. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9. View Related Products by Target STAT Solid Tumors |
| Molecular Formula | C28H23NO4S |
|---|---|
| Molecular Weight | 469.555 |