537674-89-8
537674-89-8 structure
- Name: STX-681
- Chemical Name: STX-681
- CAS Number: 537674-89-8
- Molecular Formula: C16H13BrN6O3S
- Molecular Weight: 449.283
- Create Date: 2020-01-20 15:00:57
- Modify Date: 2024-08-28 14:37:10
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A novel potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with ICI0 of 0.82 nM and 39 nM, respectively; significantly reduces plasma E2 levels, completely inhibits the growth of both MCF-7(STS) tumor growth and MCF-7(AROM) tumor in a xenograft nude mouse model.
| Name | STX-681 |
|---|
| Description | A novel potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with ICI0 of 0.82 nM and 39 nM, respectively; significantly reduces plasma E2 levels, completely inhibits the growth of both MCF-7(STS) tumor growth and MCF-7(AROM) tumor in a xenograft nude mouse model. |
|---|---|
| References | References 1. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77. 2. Woo LW, et al. J Med Chem. 2007 Jul 26;50(15):3540-60. View Related Products by Target Steroid Sulfatase (STS) |
| Molecular Formula | C16H13BrN6O3S |
|---|---|
| Molecular Weight | 449.283 |