768357-45-5
768357-45-5 structure
- Name: MCL0129
- Chemical Name: MCL0129
- CAS Number: 768357-45-5
- Molecular Formula: C34H47FN4O
- Molecular Weight: 546.775
- Create Date: 2020-01-12 10:40:50
- Modify Date: 2024-09-16 19:33:25
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MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued
| Name | MCL0129 |
|---|
| Description | MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued |
|---|---|
| References | References 1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. 2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. View Related Products by Target Melanocortin Receptor Depression |
| Molecular Formula | C34H47FN4O |
|---|---|
| Molecular Weight | 546.775 |