854091-96-6
854091-96-6 structure
- Name: CMA-008
- Chemical Name: CMA-008
- CAS Number: 854091-96-6
- Molecular Formula: C8H9IN2O3
- Molecular Weight: 308.075
- Create Date: 2020-01-20 16:29:56
- Modify Date: 2024-06-08 12:28:08
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CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM); selectively ablates NAADP-dependent Ca2+ oscillations induced by the external gastric peptide hormone agonist cholecystokinin (CCK) in murine pancreatic acinar cells.
| Name | CMA-008 |
|---|
| Description | CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM); selectively ablates NAADP-dependent Ca2+ oscillations induced by the external gastric peptide hormone agonist cholecystokinin (CCK) in murine pancreatic acinar cells. |
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| References | References 1. Dowden J, et al. Chem Biol. 2006 Jun;13(6):659-65. 2. Dammermann W, et al. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10678-83. View Related Products by Target Other Targets |
| Molecular Formula | C8H9IN2O3 |
|---|---|
| Molecular Weight | 308.075 |