865317-30-2
865317-30-2 structure
- Name: CDK5 inhibitor 20-223
- Chemical Name: CDK5 inhibitor 20-223
- CAS Number: 865317-30-2
- Molecular Formula: C19H19N3O
- Molecular Weight: 305.381
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-01-11 20:27:49
- Modify Date: 2024-01-11 18:52:28
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CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9; decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines; reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM; effectively slows tumor progression in mice models.
| Name | CDK5 inhibitor 20-223 |
|---|
| Description | CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9; decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines; reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM; effectively slows tumor progression in mice models. |
|---|---|
| References | References 1. Robb CM, et al. Oncotarget. 2017 Dec 28;9(4):5216-5232. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C19H19N3O |
|---|---|
| Molecular Weight | 305.381 |