CDK5 inhibitor 20-223
Modify Date: 2024-01-11 18:52:28
CDK5 inhibitor 20-223 structure
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Common Name | CDK5 inhibitor 20-223 | ||
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| CAS Number | 865317-30-2 | Molecular Weight | 305.381 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CDK5 inhibitor 20-223CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9; decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines; reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM; effectively slows tumor progression in mice models. |
| Name | CDK5 inhibitor 20-223 |
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| Description | CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9; decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines; reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM; effectively slows tumor progression in mice models. |
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| References | References 1. Robb CM, et al. Oncotarget. 2017 Dec 28;9(4):5216-5232. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C19H19N3O |
|---|---|
| Molecular Weight | 305.381 |