924471-88-5
924471-88-5 structure
- Name: NGI-1 derivative C-19
- Chemical Name: NGI-1 derivative C-19
- CAS Number: 924471-88-5
- Molecular Formula: C21H25N3O4S
- Molecular Weight: 415.508
- Create Date: 2020-01-11 18:56:49
- Modify Date: 2024-01-17 01:32:52
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NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A; reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells; NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).
| Name | NGI-1 derivative C-19 |
|---|
| Description | NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A; reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells; NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR). |
|---|---|
| References | References 1. Rinis N, et al. Cell Chem Biol. 2018 Jul 24. pii: S2451-9456(18)30232-0. View Related Products by Target Other Targets |
| Molecular Formula | C21H25N3O4S |
|---|---|
| Molecular Weight | 415.508 |