937735-00-7
937735-00-7 structure
- Name: QM31
- Chemical Name: QM31
- CAS Number: 937735-00-7
- Molecular Formula: C39H38Cl4N4O4
- Molecular Weight: 768.557
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2020-01-20 00:21:57
- Modify Date: 2024-01-08 20:15:54
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QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9; suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint; QM31 can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest.
| Name | QM31 |
|---|
| Description | QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9; suppresses the Apaf-1-dependent intra-S-phase DNA damage checkpoint; QM31 can interfere with the two known functions of Apaf-1, namely apoptosome assembly/activation and intra-S-phase cell cycle arrest. |
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| References | References 1. Mondragón L, et al. Apoptosis. 2009 Feb;14(2):182-90. 2. Mondragón L, et al. J Med Chem. 2008 Feb 14;51(3):521-9. 3. Malet G, et al. Cell Death Differ. 2006 Sep;13(9):1523-32. View Related Products by Target Apaf-1 |
| Molecular Formula | C39H38Cl4N4O4 |
|---|---|
| Molecular Weight | 768.557 |