958227-46-8
958227-46-8 structure
- Name: BI 831266
- Chemical Name: BI 831266
- CAS Number: 958227-46-8
- Molecular Formula: C27H38ClN7O2
- Molecular Weight: 528.098
- Create Date: 2020-01-12 08:17:49
- Modify Date: 2024-04-07 17:46:22
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BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM; inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM); causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC). Solid Tumors Phase 1 Clinical
| Name | BI 831266 |
|---|
| Description | BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM; inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM); causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC). Solid Tumors Phase 1 Clinical |
|---|---|
| References | References 1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22. View Related Products by Target Aurora Kinase Solid Tumors |
| Molecular Formula | C27H38ClN7O2 |
|---|---|
| Molecular Weight | 528.098 |