1062444-54-5

1062444-54-5 structure

Name: 1V209
Chemical Name: 1V209
CAS Number: 1062444-54-5
Molecular Formula: C₁₆H₁₇N₅O₅
Molecular Weight: 359.34
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2020-01-24 08:12:51
Modify Date: 2024-01-20 11:53:47
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity[1][2].

Name	1V209

Description	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
Target	TLR7
In Vitro	1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells[1]. 1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells[1].
In Vivo	The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration[1].
References	[1]. Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105. [2]. Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23.

Molecular Formula	C₁₆H₁₇N₅O₅
Molecular Weight	359.34

Hazard Codes	Xi