117041-96-0
117041-96-0 structure
- Name: 2-Methylcitric acid trisodium
- Chemical Name: 2-Methylcitric acid trisodium
- CAS Number: 117041-96-0
- Molecular Formula: C7H7Na3O7
- Molecular Weight: 272.10
- Catalog: Research Areas Metabolic Disease
- Create Date: 2020-01-23 22:17:51
- Modify Date: 2025-08-25 12:24:01
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2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
| Name | 2-Methylcitric acid trisodium |
|---|
| Description | 2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1]. 2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1]. 2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1]. 2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1]. 2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1]. 2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1]. |
| References |
| Molecular Formula | C7H7Na3O7 |
|---|---|
| Molecular Weight | 272.10 |
| RIDADR | NONH for all modes of transport |
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