117041-96-0

117041-96-0 structure

Name: 2-Methylcitric acid trisodium
Chemical Name: 2-Methylcitric acid trisodium
CAS Number: 117041-96-0
Molecular Formula: C₇H₇Na₃O₇
Molecular Weight: 272.10
Catalog: Research Areas Metabolic Disease
Create Date: 2020-01-23 22:17:51
Modify Date: 2024-01-14 19:06:03
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

Name	2-Methylcitric acid trisodium

Description	2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1]. 2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1]. 2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1]. 2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1]. 2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1]. 2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].
References	[1]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10.

Molecular Formula	C₇H₇Na₃O₇
Molecular Weight	272.10

RIDADR	NONH for all modes of transport

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