2230757-47-6

2230757-47-6 structure

Name: ACP-5862
Chemical Name: ACP-5862
CAS Number: 2230757-47-6
Molecular Formula: C₂₆H₂₃N₇O₃
Molecular Weight: 481.51
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2020-01-23 13:23:51
Modify Date: 2024-01-02 21:32:44
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK)[1]. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[2].

Name	ACP-5862

Description	ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK)[1]. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Target	IC50: 5.0 nM (BTK)[1]
References	[1]. Podoll T, et al. Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans. Drug Metab Dispos. 2019 Feb;47(2):145-154. [2]. Herman SE, et al. The Bruton's tyrosine kinase (BTK) inhibitor acalabrutinib demonstrates potent on-target effects and efficacy in two mouse models of chronic lymphocytic leukemia. Clin Cancer Res. 2016 Nov 30

Molecular Formula	C₂₆H₂₃N₇O₃
Molecular Weight	481.51