1631164-24-3
1631164-24-3 structure
- Name: BAY-784
- Chemical Name: BAY-784
- CAS Number: 1631164-24-3
- Molecular Formula: C29H26ClF4N3O5S2
- Molecular Weight: 672.11
- Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
- Create Date: 2020-01-23 23:49:51
- Modify Date: 2024-02-04 08:41:19
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BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].
| Name | BAY-784 |
|---|
| Description | BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1] |
| In Vivo | BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1]. Animal Model: OVX rats[1] Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis) Administration: Single p.o. Result: ED50=4.5 mg/kg (4/8 h). The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively. |
| References |
| Molecular Formula | C29H26ClF4N3O5S2 |
|---|---|
| Molecular Weight | 672.11 |