1947408-74-3
1947408-74-3 structure
- Name: Cysteine thiol probe
- Chemical Name: Cysteine thiol probe
- CAS Number: 1947408-74-3
- Molecular Formula: C11H12BrNO3S
- Molecular Weight: 318.19
- Catalog: Research Areas Others
- Create Date: 2020-01-23 18:19:51
- Modify Date: 2024-04-06 18:32:12
-
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites[1][2].
| Name | Cysteine thiol probe |
|---|
| Description | Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Cysteine Thiol Probe (Probe 1) reacts much more readily with β-lactam- and β-lactone-based electrophilic natural products, and its reactivity with epoxide-based electrophilic natural products is poor. And probe 2 reacts much faster with epoxide-containing natural products. This orthogonal reactivity allows them to be employed in extracts simultaneously. Since Cysteine Thiol Probe is brominated and probe 2 is chlorinated, the isotopic patterns of labeled natural products point toward their structural origin. Competition experiments using Cysteine Thiol Probe and 2 indicated that brominated Cysteine Thiol Probe reacted exclusively with the β-lactam in penicillin G and the β-lactone in salinosporamide A while chlorinated probe 2 alone reacted with the epoxide in salinamide A[1]. |
| References |
| Molecular Formula | C11H12BrNO3S |
|---|---|
| Molecular Weight | 318.19 |
| Storage condition | 2-8°C |