1449756-87-9

1449756-87-9 structure

Name: HCV-IN-7 hydrochloride
Chemical Name: HCV-IN-7 hydrochloride
CAS Number: 1449756-87-9
Molecular Formula: C₄₀H₅₀Cl₂N₈O₆S
Molecular Weight: 841.85
Catalog: Signaling Pathways Anti-infection HCV
Create Date: 2020-01-23 20:50:51
Modify Date: 2024-01-11 00:07:06
HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1].

Name	HCV-IN-7 hydrochloride

Description	HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HCV
Target	IC50: 3-47 pM (genotypic HCV NS5A)[1]
In Vitro	HCV-IN-7 hydrochloride inhibits GT1b (IC50=12 pM), GT2a (IC50=5 pM), GT1a (IC50=27 pM), GT3a (IC50=47 pM), GT4a (IC50=3 pM), GT6a (IC50=28 pM)[1]. HCV-IN-7 hydrochloride (10 µM) has 12%, 42%, 12% inhibition for CYP2D6, CYP2C9, CYP3A4, respectively[1]. HCV-IN-7 hydrochloride (10 µM) has cytotoxicity of 14%, 22%, 36% in Huh7, HepG2 and HEK cells, respectively[1]. HCV-IN-7 hydrochloride has a less complex central tricyclic core as novel and potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile[1].
In Vivo	HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 2 hours, CL of 11 mL/min/kg, and a Vss of 2 L/kg for rats[1]. HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 1 μM and an AUClast of 6 μM for rats[1]. HCV-IN-7 hydrochloride (iv; 1 mg/kg) has a T1/2 of 4 hours, CL of 6 mL/min/kg, and a Vss of 2 L/kg for dog[1]. HCV-IN-7 hydrochloride (po; 10 mg/kg) has a Cmax of 5 μM and an AUClast of 49 μM for dog[1].
References	[1]. Ramdas V, et al. Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate. J Med Chem. 2019 Dec 12;62(23):10563-10582.

Molecular Formula	C₄₀H₅₀Cl₂N₈O₆S
Molecular Weight	841.85

1449756-87-9	1449756-86-8
1009119-83-8	2058080-25-2
2425804-98-2	2757963-82-7
1998705-62-6	2757963-83-8
1007882-23-6	1401839-25-5
2228223-92-3	1158522-08-7
940364-43-2	2229582-46-9
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	2107533-48-0