207613-14-7
207613-14-7 structure
- Name: Mal-amido-(CH2COOH)2
- Chemical Name: Mal-amido-(CH2COOH)2
- CAS Number: 207613-14-7
- Molecular Formula: C11H12N2O7
- Molecular Weight: 284.22
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2020-01-23 14:34:51
- Modify Date: 2024-03-01 16:07:32
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Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].
| Name | Mal-amido-(CH2COOH)2 |
|---|
| Description | Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1]. |
|---|---|
| Related Catalog | |
| Target |
Cleavable |
| In Vitro | Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1]. |
| In Vivo | ADC Linker |
| References |
| Molecular Formula | C11H12N2O7 |
|---|---|
| Molecular Weight | 284.22 |