Mal-amido-(CH2COOH)2

Modify Date: 2024-03-01 16:07:32

Mal-amido-(CH2COOH)2 structure	Common Name	Mal-amido-(CH2COOH)2
	CAS Number	207613-14-7	Molecular Weight	284.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₂N₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mal-amido-(CH2COOH)2

Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].

Name	Mal-amido-(CH2COOH)2

Description	Mal-amido-(CH2COOH)2, compound 7a, is a maleimidoethyl-containing intermediate for hydrophilic ADC linker[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	Mal-amido-(CH2COOH)2 is a intermediate for linker. Bivalent doxorubicin (DOX)-dipeptides (16a-c) are finally prepared and conjugated to the monoclonal antibody BR96. The dipeptides are cleaved by lysosomal proteases following internalization of the resulting immunoconjugates[1].
In Vivo	ADC Linker
References	[1]. Dubowchik GM, et al. Doxorubicin immunoconjugates containing bivalent, lysosomally-cleavable dipeptide linkages.Bioorg Med Chem Lett. 2002 Jun 3;12(11):1529-32.

Molecular Formula	C₁₁H₁₂N₂O₇
Molecular Weight	284.22

DC Chemicals Limited
China
Product Name: Mal-amido-(CH2COOH)2
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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