1060524-97-1
1060524-97-1 structure
- Name: NUCC-390
- Chemical Name: NUCC-390
- CAS Number: 1060524-97-1
- Molecular Formula: C23H33N5O
- Molecular Weight: 395.54
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2020-01-23 17:56:51
- Modify Date: 2024-01-16 09:41:30
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NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors[1].
| Name | NUCC-390 |
|---|
| Description | NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors[1]. |
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| Related Catalog | |
| Target |
CXCR4 |
| In Vitro | NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1]. NUCC-390 (10 μM) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1]. NUCC-390 exhibited the ability to induce CXCR4 receptor internalization, we assessed the cellular localization of YFP-tagged CXCR4 receptors expressed in HEK293 cells following treatment with SDF-1 or NUCC-390[1]. NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non--treated cells exhibits some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1]. Western Blot Analysis[1] Cell Line: C8161 cells Concentration: 10 μM Incubation Time: Result: Increased the level of pERK[1]. |
| References |
| Molecular Formula | C23H33N5O |
|---|---|
| Molecular Weight | 395.54 |