NUCC-390
Modify Date: 2025-09-12 07:43:34
NUCC-390 structure
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Common Name | NUCC-390 | ||
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| CAS Number | 1060524-97-1 | Molecular Weight | 395.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H33N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NUCC-390NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors[1]. |
| Name | NUCC-390 |
|---|
| Description | NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 can induce internalization of CXCR4 receptors[1]. |
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| Related Catalog | |
| Target |
CXCR4 |
| In Vitro | NUCC-390 (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100[1]. NUCC-390 (10 μM) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors[1]. NUCC-390 exhibited the ability to induce CXCR4 receptor internalization, we assessed the cellular localization of YFP-tagged CXCR4 receptors expressed in HEK293 cells following treatment with SDF-1 or NUCC-390[1]. NUCC-390 (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non--treated cells exhibits some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells[1]. Western Blot Analysis[1] Cell Line: C8161 cells Concentration: 10 μM Incubation Time: Result: Increased the level of pERK[1]. |
| References |
| Molecular Formula | C23H33N5O |
|---|---|
| Molecular Weight | 395.54 |
| InChIKey | QUEIKILOAGDRRO-UHFFFAOYSA-N |
| SMILES | CCCn1nc(C(=O)N2CCCCC2)c2c1CCC(NCCc1ccncc1)C2 |