1206170-62-8
1206170-62-8 structure
- Name: TC Mps1 12
- Chemical Name: TC-Mps1-12
- CAS Number: 1206170-62-8
- Molecular Formula: C17H20N6O
- Molecular Weight: 324.38
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Mps1
- Create Date: 2020-01-23 13:12:51
- Modify Date: 2024-01-05 06:45:23
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TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM[1].
| Name | TC-Mps1-12 |
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| Description | TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 6.4 nM (Mps1)[1] |
| In Vitro | TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay[1]. TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC50 values of 0.84 μM[1]. Cell Viability Assay[1] Cell Line: 549 cells Concentration: Incubation Time: 72 hours Result: Inhibited the growth of cells in a dose-dependent manner and with an IC50 values of 0.84 μM. |
| In Vivo | TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss[1]. TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg[1]. Animal Model: A549 mouse xenograft model[1] Dosage: 25 mg/kg, 50 mg/kg, 100 mg/kg Administration: Oral administration; once daily; for 19 days Result: Inhibited the growth of A549 cells in a dose-dependent manner. Animal Model: A549 mouse xenograft model (pharmacokinetic )[1] Dosage: 25 mg/kg Administration: Oral administration Result: Cmax = 3542 ng/mL, AUC = 6604 ng h/mL |
| References |
| Molecular Formula | C17H20N6O |
|---|---|
| Molecular Weight | 324.38 |