2305936-56-3
2305936-56-3 structure
- Name: TD-165
- Chemical Name: TD-165
- CAS Number: 2305936-56-3
- Molecular Formula: C46H59N7O8S
- Molecular Weight: 870.07
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2020-01-23 19:06:51
- Modify Date: 2024-01-21 07:10:18
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TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1].
| Name | TD-165 |
|---|
| Description | TD-165 is a cereblon (CRBN) degrader. TD-165comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1]. |
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| Related Catalog | |
| Target |
Cereblon:20.4 nM (DC50) |
| In Vitro | TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1]. TD-165 (0.1-10 μM; 24 hours) lead to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1]. Cell Viability Assay[1] Cell Line: HEK293T cells Concentration: 0-100 nM Incubation Time: 24 hours Result: Exhibited an DC50 value of 20.4 nM. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.1, 1, and 10 μM Incubation Time: 24 hours Result: Decreased the level of CRBN protein. |
| References |
| Molecular Formula | C46H59N7O8S |
|---|---|
| Molecular Weight | 870.07 |
| Hazard Codes | Xi |
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