2216753-86-3
2216753-86-3 structure
- Name: LYN-1604 hydrochloride
- Chemical Name: 1-{4-[2-(2,4-Dichlorophenyl)-2-(2-naphthylmethoxy)ethyl]-1-piperazinyl}-2-(diisobutylamino)ethanone hydrochloride (1:1)
- CAS Number: 2216753-86-3
- Molecular Formula: C33H44Cl3N3O2
- Molecular Weight: 621.080
- Create Date: 2020-02-11 05:11:14
- Modify Date: 2025-08-28 21:38:23
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LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
| Name | 1-{4-[2-(2,4-Dichlorophenyl)-2-(2-naphthylmethoxy)ethyl]-1-piperazinyl}-2-(diisobutylamino)ethanone hydrochloride (1:1) |
|---|---|
| Synonyms |
Ethanone, 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-, hydrochloride (1:1)
1-{4-[2-(2,4-Dichlorophenyl)-2-(2-naphthylmethoxy)ethyl]-1-piperazinyl}-2-(diisobutylamino)ethanone hydrochloride (1:1) MFCD31630830 |
| Molecular Formula | C33H44Cl3N3O2 |
|---|---|
| Molecular Weight | 621.080 |
| Exact Mass | 619.249939 |
| Hazard Codes | Xn |
|---|