102925-39-3
102925-39-3 structure
- Name: β-adrenergic-receptor kinase
- Chemical Name: β-adrenergic-receptor kinase
- CAS Number: 102925-39-3
- Molecular Formula:
- Molecular Weight:
- Create Date: 2020-04-10 14:42:37
- Modify Date: 2024-01-29 17:34:45
-
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase). Reaction: ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor]
| Name | β-adrenergic-receptor kinase |
|---|---|
| Synonyms |
EC 2.7.11.15
ATP:β-adrenergic-receptor phosphotransferase [β-adrenergic-receptor] kinase β-adrenergic receptor-specific kinase β-AR kinase β-ARK β-ARK 1 β-ARK 2 β-receptor kinase GRK2 GRK3 β-adrenergic-receptor kinase (phosphorylating) β2ARK βARK1 β-adrenoceptor kinase β-adrenoceptor kinase 1 β-adrenoceptor kinase 2 ADRBK1 BARK1 adrenergic receptor kinase STK15 |
| Description | Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase). Reaction: ATP + [β-adrenergic receptor] = ADP + phospho-[β-adrenergic receptor] |
|---|
| No Any Chemical & Physical Properties |