2100306-70-3

2100306-70-3 structure

Name: Aminooxy-PEG1-azide
Chemical Name: Aminooxy-PEG1-azide
CAS Number: 2100306-70-3
Molecular Formula: C₄H₁₀N₄O₂
Molecular Weight: 146.15
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-04-08 14:56:30
Modify Date: 2024-01-14 20:29:20
Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	Aminooxy-PEG1-azide

Description	Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.