137417-08-4

137417-08-4 structure

Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Chemical Name: Dihydrexidine hydrochloride
CAS Number: 137417-08-4
Molecular Formula: C₁₇H₁₈ClNO₂
Molecular Weight: 303.78
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2020-04-10 23:07:02
Modify Date: 2024-01-12 17:59:48
Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4].

Name	Dihydrexidine hydrochloride

Description	Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D2 dopamine receptor)[1]
In Vivo	Dihydrexidine hydrochloride has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3]. Dihydrexidine hydrochloride (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4]. Animal Model: Adult male Sprague–Dawley rats (275-300 g)[4] Dosage: 3 mg/kg Administration: Intraperitoneal injection Result: Produces prominent dopamine D1 receptor agonist effects in vivo.
References	[1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. [2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42. [4]. Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186(1), 25–31.

Molecular Formula	C₁₇H₁₈ClNO₂
Molecular Weight	303.78

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1566501-68-5	1698699-75-0
1929360-80-4	1566958-41-5
1566997-25-8	1566914-18-8
1564462-08-3	1566762-34-2
1567083-92-4	1564799-92-3