2093401-85-3
2093401-85-3 structure
- Name: OTS186935 trihydrochloride
- Chemical Name: OTS186935 trihydrochloride
- CAS Number: 2093401-85-3
- Molecular Formula: C25H29Cl4N5O2
- Molecular Weight: 573.34
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-04-11 15:38:42
- Modify Date: 2024-01-06 21:42:59
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OTS186935 trihydrochloride is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 trihydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS186935 trihydrochloride regulates the production of γ-H2AX in cancer cells[1].
| Name | OTS186935 trihydrochloride |
|---|
| Description | OTS186935 trihydrochloride is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 trihydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS186935 trihydrochloride regulates the production of γ-H2AX in cancer cells[1]. |
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| Related Catalog | |
| Target |
IC50: 6.49 nM (SUV39H2)[1] |
| In Vitro | OTS186935 trihydrochloride inhibits A549 cell growth with IC50 of 0.67 μM[1]. |
| In Vivo | OTS186935 trihydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1]. Animal Model: Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )[1] Dosage: 10 mg/kg Administration: Intravenously; once daily for 14 days Result: Tumor growth inhibition of 42.6% on day 14. Animal Model: Female BALB/cAJcl-nu/nu mice (bearing A549 cells)[1] Dosage: 25 mg/kg Administration: Intravenously; once daily for 14 days Result: Yielded a tumor growth inhibition of 60.8% without significant body weight loss or toxicity. |
| References |
| Molecular Formula | C25H29Cl4N5O2 |
|---|---|
| Molecular Weight | 573.34 |