2093387-50-7

2093387-50-7 structure

Name: Thalidomide-NH-C4-NH2 TFA
Chemical Name: Thalidomide-NH-C4-NH2 TFA
CAS Number: 2093387-50-7
Molecular Formula: C₁₉H₂₁F₃N₄O₆
Molecular Weight: 458.39
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-04-11 15:48:05
Modify Date: 2024-01-10 10:05:58
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].

Name	Thalidomide-NH-C4-NH2 TFA
Synonyms	MFCD13184969

Description	Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
References	[1]. Jiang F, et al. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies. Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Molecular Formula	C₁₉H₂₁F₃N₄O₆
Molecular Weight	458.39

Hazard Codes	Xi