361543-12-6

361543-12-6 structure

Name: Amino-PEG12-amine
Chemical Name: Amino-PEG12-amine
CAS Number: 361543-12-6
Molecular Formula: C₂₆H₅₆N₂O₁₂
Molecular Weight: 588.73
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-02 07:17:16
Modify Date: 2024-01-09 01:34:09
Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Amino-PEG12-amine

Description	Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.