136135-57-4

136135-57-4 structure
136135-57-4 structure
  • Name: Amphotericin X1
  • Chemical Name: Amphotericin X1
  • CAS Number: 136135-57-4
  • Molecular Formula: C48H75NO17
  • Molecular Weight: 938.11
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2020-06-01 22:09:06
  • Modify Date: 2024-01-22 09:59:38
  • Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1].

Name Amphotericin X1
Description Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1].
Related Catalog
Target

MIC: 1 μg/mL (Candida albicans 33/079), 8 μg/mL (C.parapsilosis 937A), 1 μg/mL (Cryptococcus neoformans 451), 2 μg/mL (Aspergillus niger 57A) and 2 μg/mL (A.fumigatus)[1]

In Vitro Amphotericin X1 (compound 4) shows interesting antifungal activity combined with a pronounced reduction in haemolytic activity (EH50 of 42 μg/mL) against mammalianerythrocytes in vitro[1].
References

[1]. Taylor AW, et al. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position. J Antibiot (Tokyo). 1993 Mar;46(3):486-93.

Molecular Formula C48H75NO17
Molecular Weight 938.11