1679330-37-0

1679330-37-0 structure

1679330-37-0 structure

Name: AZ Dyrk1B 33
Chemical Name: AZ-Dyrk1B-33
CAS Number: 1679330-37-0
Molecular Formula: C₁₉H₁₆N₄
Molecular Weight: 300.36
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2020-06-04 08:32:03
Modify Date: 2024-01-10 13:20:37
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].

Name	AZ-Dyrk1B-33

Description	AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Metabolic Disease
Target	IC50: 7 nM (Dyrk1B)[1]
In Vitro	AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM[1]. AZ-Dyrk1B-33 shows no effect in sensitization[1].
References	[1]. Kettle JG, et al. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J Med Chem. 2015 Mar 26;58(6):2834-44.

Molecular Formula	C₁₉H₁₆N₄
Molecular Weight	300.36