1068148-47-9

1068148-47-9 structure

Name: BIBP3226trifluoroacetate
Chemical Name: BIBP3226 TFA
CAS Number: 1068148-47-9
Molecular Formula: C₂₉H₃₂F₃N₅O₅
Molecular Weight: 587.59
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2020-06-01 18:57:17
Modify Date: 2024-01-12 12:27:34
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].

Name	BIBP3226 TFA

Description	BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
Target	rNPY Y1 receptor:1.1 nM (Ki) hNPFF2:79 nM (Ki) rNPFF:108 nM (Ki)
In Vivo	BIBP3226 (0.5, 5μg; i.c.v.) induces an anxiogenic-like effect at the higher dose[1]. Animal Model: Male Wistar rats 270-350 g[1] Dosage: 0.5, 5μg Administration: I.c.v Result: At the dose of 5μg caused an anxiogenic-like effect while the lower dose was ineffective.
References	[1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4. [2]. Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317(2-3):R3-4.

Molecular Formula	C₂₉H₃₂F₃N₅O₅
Molecular Weight	587.59