2353409-98-8

2353409-98-8 structure

Name: DBCO-PEG6-amine,DBCO-PEG6-NH2
Chemical Name: DBCO-PEG6-amine
CAS Number: 2353409-98-8
Molecular Formula: C₃₃H₄₅N₃O₈
Molecular Weight: 611.73
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 11:09:02
Modify Date: 2024-01-09 17:48:47
DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	DBCO-PEG6-amine

Description	DBCO-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562