1394079-41-4

1394079-41-4 structure

1394079-41-4 structure

Name: DGN462
Chemical Name: DGN462
CAS Number: 1394079-41-4
Molecular Formula: C₅₃H₅₉N₅O₉S
Molecular Weight: 942.13
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA Alkylator/Crosslinker
Create Date: 2020-06-01 15:10:06
Modify Date: 2024-01-04 13:23:31
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1].

Name	DGN462

Description	DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker
In Vitro	DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class[1].
References	[1]. Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639.

Molecular Formula	C₅₃H₅₉N₅O₉S
Molecular Weight	942.13