1952360-91-6

1952360-91-6 structure

Name: (Fmoc-amino)-PEG12-C2-Carboxylic Acid
Chemical Name: Fmoc-NH-PEG12-CH2CH2COOH
CAS Number: 1952360-91-6
Molecular Formula: C₄₂H₆₅NO₁₆
Molecular Weight: 839.96
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 17:32:05
Modify Date: 2024-01-04 14:43:11
Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Fmoc-NH-PEG12-CH2CH2COOH

Description	Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562